USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: MYH9_HUMAN USC-OGP 2-DE database:  MYH9_HUMAN MYH9_HUMAN General information about the entry View entry in simple text format Entry name MYH9_HUMAN Primary accession number P35579 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Myosin-9; AltName: Full=Cellular myosin heavy chain, type A; AltName: Full=Myosin heavy chain 9; AltName: Full=Myosin heavy chain, non-muscle IIa; AltName: Full=Non-muscle myosin heavy chain A; Short=NMMHC-A; AltName: Full=Non-muscle myosin heavy chain IIa; Short=NMMHC II-a; Short=NMMHC-IIA;. Gene name Name=MYH9 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1096: pI=5.26; Mw=148284 SPOT OGP-1188: pI=6.62; Mw=42327 SPOT OGP-1274: pI=6.07; Mw=27522 Cross-references UniProtKB/Swiss-Prot P35579; MYH9_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name MYH9_HUMAN Primary accession number P35579 Secondary accession number(s) A8K6E4 O60805 Q60FE2 Q86T83 Sequence was last modified on  January 23, 2007 (version 4) Annotations were last modified on  March 15, 2017 (version 203) Name and origin of the protein Description RecName: Full=Myosin-9; AltName: Full=Cellular myosin heavy chain, type A; AltName: Full=Myosin heavy chain 9; AltName: Full=Myosin heavy chain, non-muscle IIa; AltName: Full=Non-muscle myosin heavy chain A; Short=NMMHC-A; AltName: Full=Non-muscle myosin heavy chain IIa; Short=NMMHC II-a; Short=NMMHC-IIA; Gene name Name=MYH9 Encoded on Name=MYH9 Keywords 3D-structure; Acetylation; Actin-binding; Alport syndrome; Alternative splicing; ATP-binding; Calmodulin-binding; Cataract; Cell adhesion; Cell shape; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Deafness; Direct protein sequencing; Disease mutation; Motor protein; Myosin; Non-syndromic deafness; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL CR456526; CAG30412.1; -; mRNA EMBL AB191263; BAD52439.1; -; mRNA EMBL AL832639; CAD89954.1; ALT_FRAME; mRNA EMBL AB290175; BAG06729.1; -; mRNA EMBL Z82215; CAB05105.1; -; Genomic_DNA EMBL CH471095; EAW60096.1; -; Genomic_DNA EMBL M81105; AAA59888.1; -; mRNA EMBL AK291609; BAF84298.1; -; mRNA EMBL M69180; AAA61765.1; -; mRNA EMBL M31013; AAA36349.1; -; mRNA CCDS CCDS13927.1; -. [P35579-1]; . PIR A61231; A61231; . RefSeq NP_002464.1; NM_002473.5. [P35579-1]; . RefSeq XP_011528499.1; XM_011530197.2. [P35579-1]; . RefSeq XP_016884292.1; XM_017028803.1. [P35579-1]; . RefSeq XP_016884293.1; XM_017028804.1. [P35579-1]; . RefSeq XP_016884294.1; XM_017028805.1. [P35579-1]; . RefSeq XP_016884295.1; XM_017028806.1. [P35579-1]; . UniGene Hs.474751; -; . PDB 2LNK; NMR; -; C=1897-1935 PDB 3ZWH; X-ray; 1.94 A; Q=1893-1937 PDB 4CFQ; X-ray; 1.37 A; Q/R=1893-1937 PDB 4CFR; X-ray; 1.40 A; Q=1893-1937 PDB 4ETO; X-ray; 1.54 A; P=1908-1923 PDBsum 2LNK; -; . PDBsum 3ZWH; -; . PDBsum 4CFQ; -; . PDBsum 4CFR; -; . PDBsum 4ETO; -; . ProteinModelPortal P35579; -; . SMR P35579; -; . BioGrid 110712; 309; . DIP DIP-33103N; -; . IntAct P35579; 269; . MINT MINT-7901706; -; . STRING 9606.ENSP00000216181; -; . ChEMBL CHEMBL2189151; -; . iPTMnet P35579; -; . PhosphoSitePlus P35579; -; . SwissPalm P35579; -; . BioMuta MYH9; -; . DMDM 6166599; -; . EPD P35579; -; . PaxDb P35579; -; . PeptideAtlas P35579; -; . PRIDE P35579; -; . TopDownProteomics P35579-1; -. [P35579-1]; . DNASU 4627; -; . Ensembl ENST00000216181; ENSP00000216181; ENSG00000100345. [P35579-1]; . GeneID 4627; -; . KEGG hsa:4627; -; . UCSC uc003apg.4; human. [P35579-1]; . CTD 4627; -; . DisGeNET 4627; -; . GeneCards MYH9; -; . GeneReviews MYH9; -; . HGNC HGNC:7579; MYH9; . HPA CAB015386; -; . HPA HPA001644; -; . MalaCards MYH9; -; . MIM 153640; phenotype; . MIM 153650; phenotype; . MIM 155100; phenotype; . MIM 160775; gene; . MIM 600208; phenotype; . MIM 603622; phenotype; . MIM 605249; phenotype; . neXtProt NX_P35579; -; . OpenTargets ENSG00000100345; -; . Orphanet 90635; Autosomal dominant non-syndromic sensorineural deafness type DFNA; . Orphanet 182050; MYH9-related disease; . PharmGKB PA31377; -; . eggNOG KOG0161; Eukaryota; . eggNOG COG5022; LUCA; . GeneTree ENSGT00760000118919; -; . HOGENOM HOG000173958; -; . HOVERGEN HBG004704; -; . InParanoid P35579; -; . KO K10352; -; . OMA FEDECAN; -; . OrthoDB EOG091G009J; -; . PhylomeDB P35579; -; . TreeFam TF333601; -; . Reactome R-HSA-2029482; Regulation of actin dynamics for phagocytic cup formation; . Reactome R-HSA-3928663; EPHA-mediated growth cone collapse; . Reactome R-HSA-416572; Sema4D induced cell migration and growth-cone collapse; . Reactome R-HSA-5625740; RHO GTPases activate PKNs; . Reactome R-HSA-5625900; RHO GTPases activate CIT; . Reactome R-HSA-5627117; RHO GTPases Activate ROCKs; . Reactome R-HSA-5627123; RHO GTPases activate PAKs; . SIGNOR P35579; -; . ChiTaRS MYH9; human; . GeneWiki MYH9; -; . GenomeRNAi 4627; -; . PMAP-CutDB P35579; -; . PRO PR:P35579; -; . Proteomes UP000005640; Chromosome 22; . Bgee ENSG00000100345; -; . CleanEx HS_MYH9; -; . ExpressionAtlas P35579; baseline and differential; . Genevisible P35579; HS; . GO GO:0015629; C:actin cytoskeleton; IDA:UniProtKB; . GO GO:0042641; C:actomyosin; IDA:UniProtKB; . GO GO:0005826; C:actomyosin contractile ring; IDA:UniProtKB; . GO GO:0005903; C:brush border; IEA:Ensembl; . GO GO:0031252; C:cell leading edge; IDA:UniProtKB; . GO GO:0005913; C:cell-cell adherens junction; IEA:Ensembl; . GO GO:0032154; C:cleavage furrow; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005925; C:focal adhesion; IEA:Ensembl; . GO GO:0001772; C:immunological synapse; IEA:Ensembl; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0016460; C:myosin II complex; IDA:UniProtKB; . GO GO:0097513; C:myosin II filament; IDA:UniProtKB; . GO GO:0031594; C:neuromuscular junction; IEA:Ensembl; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; IDA:UniProtKB; . GO GO:0043234; C:protein complex; IDA:UniProtKB; . GO GO:0001726; C:ruffle; IDA:UniProtKB; . GO GO:0005819; C:spindle; IEA:Ensembl; . GO GO:0001725; C:stress fiber; IDA:UniProtKB; . GO GO:0001931; C:uropod; IDA:MGI; . GO GO:0003779; F:actin binding; IDA:MGI; . GO GO:0051015; F:actin filament binding; IDA:UniProtKB; . GO GO:0030898; F:actin-dependent ATPase activity; IDA:MGI; . GO GO:0043531; F:ADP binding; IDA:MGI; . GO GO:0005524; F:ATP binding; IDA:MGI; . GO GO:0016887; F:ATPase activity; IDA:UniProtKB; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0000146; F:microfilament motor activity; IDA:UniProtKB; . GO GO:0003774; F:motor activity; NAS:UniProtKB; . GO GO:0043495; F:protein anchor; IMP:UniProtKB; . GO GO:0019904; F:protein domain specific binding; IPI:UniProtKB; . GO GO:0042803; F:protein homodimerization activity; IDA:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0031532; P:actin cytoskeleton reorganization; IMP:UniProtKB; . GO GO:0030048; P:actin filament-based movement; IDA:UniProtKB; . GO GO:0031032; P:actomyosin structure organization; IDA:UniProtKB; . GO GO:0001525; P:angiogenesis; IDA:UniProtKB; . GO GO:0043534; P:blood vessel endothelial cell migration; IMP:UniProtKB; . GO GO:0000910; P:cytokinesis; IMP:UniProtKB; . GO GO:0051295; P:establishment of meiotic spindle localization; IEA:Ensembl; . GO GO:0001768; P:establishment of T cell polarity; IEA:Ensembl; . GO GO:0001701; P:in utero embryonic development; IEA:Ensembl; . GO GO:0007229; P:integrin-mediated signaling pathway; NAS:UniProtKB; . GO GO:0050900; P:leukocyte migration; NAS:UniProtKB; . GO GO:0000212; P:meiotic spindle organization; IEA:Ensembl; . GO GO:0006509; P:membrane protein ectodomain proteolysis; IDA:UniProtKB; . GO GO:0030224; P:monocyte differentiation; IEP:UniProtKB; . GO GO:0007520; P:myoblast fusion; IEA:Ensembl; . GO GO:1903919; P:negative regulation of actin filament severing; IMP:UniProtKB; . GO GO:0006911; P:phagocytosis; engulfment; ISS:UniProtKB GO GO:0070527; P:platelet aggregation; IMP:UniProtKB; . GO GO:0030220; P:platelet formation; IMP:UniProtKB; . GO GO:1903923; P:positive regulation of protein processing in phagocytic vesicle; ISS:UniProtKB; . GO GO:0015031; P:protein transport; IMP:UniProtKB; . GO GO:0008360; P:regulation of cell shape; IMP:UniProtKB; . GO GO:0032796; P:uropod organization; IEA:Ensembl; . Gene3D 4.10.270.10; -; 1; . InterPro IPR000048; IQ_motif_EF-hand-BS; . InterPro IPR027401; Myosin-like_IQ_dom; . InterPro IPR001609; Myosin_head_motor_dom; . InterPro IPR004009; Myosin_N; . InterPro IPR002928; Myosin_tail; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR016137; RGS; . Pfam PF00063; Myosin_head; 1; . Pfam PF02736; Myosin_N; 1; . Pfam PF01576; Myosin_tail_1; 1; . PRINTS PR00193; MYOSINHEAVY; . SMART SM00015; IQ; 1; . SMART SM00242; MYSc; 1; . SUPFAM SSF48097; SSF48097; 1; . SUPFAM SSF52540; SSF52540; 1; . PROSITE PS50096; IQ; 1; . PROSITE PS51456; MYOSIN_MOTOR; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

[Home]